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Acetaminophen and caffeine are common ingredients in standard headache medicines. When these are mixed with a barbiturate such as butalbital that relax muscle contractions, they make an effective medication for the relief of tension headaches. Fioricet is a well known prescription medication that is used to treat tension headaches. The medication works by relaxing the muscle contractions which can give rise to mild or moderate headaches. The Fioricet formula consists of three main ingredients: acetaminophen which is the main pain reliever; butalbital, a barbiturate; as well as caffeine, a stimulant.